Anterior insula reactivity to loss moderates the association between trait impulsivity and future suicidal ideation in adolescents

Developmental Cognitive Neuroscience 2026 Open access

Read full text
Authors: Carly J. Lenniger, Kristen L. Eckstrand, T. H. Stanley Seah, Jennifer Susan Silk, Jamie Lars Hanson, Melissa Nance, Morgan Lindenmuth, Gretchen Haas, Neal Ryan, Erika E. Forbes
DOI: 10.1016/j.dcn.2026.101726
Cited by: 1
References: 68

Abstract

While impulsivity is a prominent risk factor for adolescent suicidal thoughts and behaviors (STB), impulsivity specifically following negative experiences shows more consistent associations. Individual differences in neural sensitivity to negative outcomes may explain why some impulsive adolescents develop STB while others do not. We examined whether neural reactivity to monetary loss moderates the relationship between impulsivity and future SI (SI). Sixty-three adolescents (ages 13-18 at baseline; 59% female) with varying familial risk for psychopathology completed impulsivity measures and an fMRI monetary win/loss paradigm at baseline, and SI assessment one year later. Moderation analyses tested whether BOLD signal extracted from significant clusters ( p FWE

Fields of Study & Subjects

Suicide and Self-Harm Studies Traumatic Brain Injury Research Death Anxiety and Social Exclusion

Publication details

Journal / source
Developmental Cognitive Neuroscience
Publisher
Elsevier BV
Volume
79
Pages
101726–101726
Publication date
23 April 2026
Language
EN