A replenishable peritoneal implant for localized delivery and peritoneal fluid sampling in ovarian cancer

Intraperitoneal (i.p.) therapy improves outcomes in abdominal cancers but remains underutilized due to complications from repurposed catheters. In this work, we present a replenishable therapeutic implant for repeated, localized delivery of therapies to the peritoneal cavity. In an ovarian cancer mouse model, expanded natural killer (eNK) cells were delivered once weekly and interleukin-15 (IL-15) thrice weekly. This regime reduced tumor burden compared to standard i.p. injection. The implant supports co-administration of chemotherapy, cytokines, monoclonal antibodies, or other protein-based therapies. Negative pressure applied via the port enabled longitudinal sampling of peritoneal fluid without additional surgical intervention. By reducing procedural burden and improving adaptability, the implant can help increase patient retention and therapeutic efficacy in ovarian cancer and other intra-abdominal cancers.