High prevalence of fatty pancreas disease in type 2 diabetes mellitus: a meta-analysis

High intrapancreatic fat deposition (IPFD), or fatty pancreas disease (FPD), has been increasingly recognized as a major driver in the pathogenesis of type 2 diabetes mellitus (T2DM). This meta-analysis aims to quantify the prevalence of FPD in people with T2DM. We searched PubMed and Embase databases until October 27, 2025, for observational studies that reported data on FPD prevalence in people with T2DM. A generalized linear mixed model was used to estimate pooled prevalence. In total, 12 studies (6,369 individuals) were included. The pooled prevalence of FPD in T2DM was 54.28% (95% CI 37.70 to 69.96). Subgroup analyses indicated that the prevalence of FPD tended to be lower in Asian than European studies (42.85% vs. 69.19%, p = 0.06) and was higher in smaller studies (