Assessing the usefulness of antibody index values from treponemal immunoassays to reduce confirmatory syphilis testing in the reverse algorithm

Diagnostic Microbiology and Infectious Disease 2026 Open access

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Authors: Mayur R. Shukla, Kiantra Butler, Kevin Pettus, Katherine Herrell, Phoebe Thorpe, Jaeyoung Hong, Arlene C. Seña, Weiping Medlin
DOI: 10.1016/j.diagmicrobio.2026.117355
Cited by: 0
References: 10

Abstract

We assessed utility of antibody index values from treponemal immunoassays against confirmatory tests following reverse syphilis algorithm. We tested sera collected from a population at increased risk and established thresholds for treponemal immunoassays. High concordance with confirmatory tests was observed, indicating potential use of assay specific threshold to reduce testing.

Fields of Study & Subjects

Syphilis Diagnosis and Treatment Bacterial Identification and Susceptibility Testing Vector-borne infectious diseases

Publication details

Journal / source
Diagnostic Microbiology and Infectious Disease
Volume
115
Issue
3
Pages
117355–117355
Publication date
3 March 2026
Language
EN