Encequidar is a multispecies gut-restricted P-glycoprotein inhibitor that delineates between intestinal secretion and biliary elimination in animals and predicts human disposition pathways

Drug Metabolism and Disposition 2026 Open access

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Authors: Murali Subramanian, Josh Yu, Gregg M. Schwarzwalder, A.B. Shodeinde, Dana J. Levine, Taera Kim, Raghavendra Jampala, Guangyu Zhao, Elizabeth M. Bacon, Raju Subramanian
DOI: 10.1016/j.dmd.2026.100237
Cited by: 0
References: 35

Abstract

Encequidar is a gut-restricted P-glycoprotein inhibitor that is a useful tool molecule to boost the oral bioavailability of P-glycoprotein substrates. In this article, we demonstrate that encequidar has moderate to high clearance and volume of distribution, and low oral bioavailabilities (

Fields of Study & Subjects

Drug Transport and Resistance Mechanisms Pharmacogenetics and Drug Metabolism Drug Solubulity and Delivery Systems

Publication details

Journal / source
Drug Metabolism and Disposition
Volume
54
Issue
3
Pages
100237–100237
Publication date
16 January 2026
Language
EN