Prediction of pharmacokinetics and central nervous system effects of fentanyl and alfentanil in mice, rats, and humans using a cross-species physiologically based pharmacokinetic–pharmacodynamic model and in vitro pharmacokinetic/pharmacodynamic parameters

Drug Metabolism and Disposition 2026

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Authors: Qingxuan Shao, Ying Deng, Weiye Gu, Yang Lu, Nan Hu, Xiaodong Liu, Li Liu

DOI: 10.1016/j.dmd.2026.100319

Cited by: 1

References: 63

Fields of Study & Subjects

Neuroscience and Neuropharmacology Research Neurotransmitter Receptor Influence on Behavior Pain Mechanisms and Treatments

References 63