Antibacterial PROTACs: the road ahead for next-generation antibiotics?
Abstract
The discovery of antibiotics revolutionized modern medicine, enabling the treatment of once-deadly bacterial infections. However, the rise of antibiotic-resistant bacteria has severely limited their effectiveness, making antimicrobial resistance (AMR) a major global health challenge. Developing new antibiotics with novel mechanisms of action is notably difficult. A promising approach is targeted protein degradation (TPD), a technology that has transformed drug discovery and shown success in cancer, neurodegenerative diseases, and immunology. In this review, we explore the potential of TPD to create next-generation antibacterials, its advantages over conventional antibiotics, and current research on prokaryotic protein degradation systems and BacPROTAC molecules.
Fields of Study & Subjects
Protein Degradation and Inhibitors
Peptidase Inhibition and Analysis
Click Chemistry and Applications
Publication details
- Journal / source
- Drug Discovery Today
- Publisher
- Elsevier BV
- Volume
- 31
- Issue
- 3
- Pages
- 104656–104656
- Publication date
- 1 April 2026
- Language
- EN