Exploring the effects of pharmacological treatments on suicidality in children and adolescents: a structured review of the literature and narrative synthesis

EClinicalMedicine 2026 Open access

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Authors: Andrea Amerio, Enrico Venturini, Mirko Capanna, Luca Ploner, Irene Schiavetti, Alessandra Costanza, Massimiliano Clausi, Paola Bertuccio, Anna Odone, Helen Minnis, Ruchika Gajwani, Renato de Filippis
+4 more Pasquale De Fazio, Mario Amore, Andrea Aguglia, Gianluca Serafini
DOI: 10.1016/j.eclinm.2025.103748
Cited by: 0
References: 47

Abstract

Background Suicide rates have risen among young people, making it a leading cause of adolescent death worldwide. Although several pharmacological treatments have been approved in the context of definite underlying conditions, their broader efficacy in reducing suicidality remains unclear. Methods A structured review was conducted on pharmacological treatments for suicidality in under 18s. PubMed, Embase, PsycINFO, and Cochrane Library were searched from inception to 31 July 2025. Eligible studies included patients

Fields of Study & Subjects

Suicide and Self-Harm Studies Treatment of Major Depression Attention Deficit Hyperactivity Disorder

Publication details

Journal / source
EClinicalMedicine
Volume
91
Pages
103748–103748
Publication date
1 January 2026
Language
EN