Morning urinary calcium/creatinine ratio as a sex-specific screening tool for detecting hypercalciuria in hypoparathyroidism

European Journal of Internal Medicine 2026 Open access

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Authors: Christina Berr, Carmina Teresa Fuß, Karen Gronemeyer, Birgit Löhr, Christian Helmut Pfob, T Pusl, Stefanie Hahner
DOI: 10.1016/j.ejim.2026.106740
Cited by: 1
References: 28

Abstract

BACKGROUND: Hypercalciuria is a relevant complication in patients with treated hypoparathyroidism. While hypercalciuria is usually estimated by 24-hour urinary calcium excretion (24hUCa), the calcium/creatinine ratio (CaCrR) of a morning urine sample is more often used in pediatric endocrinology due to feasibility. This study aims to compare these two approaches in adult patients with hypoparathyroidism. METHODS: In a cohort of 184 systematically evaluated patients with primary hypoparathyroidism (93 % postoperative, 73 % female), the 24hUCa was compared with the CaCrR of a morning spot urine at home. All patients were evaluated at two University hospitals. RESULTS: 60 % of patients met the sex-specific targets of 24hUCa (

Fields of Study & Subjects

Thyroid and Parathyroid Surgery Parathyroid Disorders and Treatments Thyroid Disorders and Treatments

Publication details

Journal / source
European Journal of Internal Medicine
Publisher
Elsevier BV
Volume
148
Pages
106740–106740
Publication date
28 February 2026
Language
EN