Synthesis and biological evaluation of phenanthridine derivatives as dual-target inhibitors of DNA topoisomerase IB (TOP1) and tyrosyl-DNA phosphodiesterase 1 (TDP1), and potential antitumor agents

European Journal of Medicinal Chemistry 2026

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Authors: Jian-Mei Gao, Huilong Xie, Zi-Qiang Wang, Yu Huang, Yifan Ouyang, Su Yan, Nan Chao, Wenbo Yan, Hui Yuan, Junxun Zhou, Mei-Mei Zhang, Mei-Mei Zhang
+9 more Jiaxin He, Zhou Hong, Jiunlong Yang, Jiunlong Yang, Yanru Fan, Chang-Cai Bai, Yu Zhang, Huang Zeng, Hao Yang
DOI: 10.1016/j.ejmech.2025.118541
Cited by: 3
References: 36

Fields of Study & Subjects

Cancer therapeutics and mechanisms Chemical Reactions and Isotopes Chemical synthesis and alkaloids

Publication details

Journal / source
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Volume
304
Pages
118541–118541
Publication date
2 January 2026
Language
EN