Discovery of novel and potent 2-aminopyrazine-based HPK1 inhibitors enhancing T-cell immunity against cancer

European Journal of Medicinal Chemistry 2026 Open access

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Authors: Zhichao Guo, Yiping Duan, Baixue Zhang, Kai Sun, Tiandong Zheng, Lanlan Chen, Chen He, Jiajie Feng, You Lü, Geting Xiong, Shengtao Xu, Jie Liu
+2 more Zheying Zhu, Jinyi Xu
DOI: 10.1016/j.ejmech.2026.118689
Cited by: 1
References: 46

Fields of Study & Subjects

Melanoma and MAPK Pathways NF-κB Signaling Pathways Protein Tyrosine Phosphatases

Publication details

Journal / source
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Volume
308
Pages
118689–118689
Publication date
18 February 2026
Language
EN