Discovery of HDM2004, a potent, selective and orally bioavailable HPK1 inhibitor for tumor immunotherapy

European Journal of Medicinal Chemistry 2026

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Authors: Zhimin Zhang, Minhao Huang, E Jingwen, Zhiping Zhang, Tao Deng, Yacheng Yang, Yina Sun, Junjie Zou, Xiaohua Zhang, Tingni Chen, Dongzhou Jeffrey Liu
DOI: 10.1016/j.ejmech.2026.118708
Cited by: 1
References: 32

Fields of Study & Subjects

Protein Tyrosine Phosphatases Phytochemical Studies and Bioactivities PI3K/AKT/mTOR signaling in cancer

Publication details

Journal / source
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Volume
308
Pages
118708–118708
Publication date
20 February 2026
Language
EN