InhibitWin duo: Rational design and structural insights into dual PARP/HDAC inhibitors for synergistic DNA repair disruption and epigenetic modulation

European Journal of Medicinal Chemistry 2026

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Authors: Eman M Elkafoury, Tarek Faathy El-Moselhy, Mervat H. El‐Hamamsy, Eman A. El-Bastawissy, Kamyar Afarinkia, Mohammed A. M. Salih, Ashraf K. El-Damasy, MA Ibrahim, Ahmed Elshewy, Ahmed M. Shawky, Rabah N. Alsulami, Othman Alzahrani
+2 more Laila A. Jaragh-Alhadad, Peter A. Sidhom
DOI: 10.1016/j.ejmech.2026.118743
Cited by: 2
References: 136

Fields of Study & Subjects

PARP inhibition in cancer therapy Protein Degradation and Inhibitors Histone Deacetylase Inhibitors Research

Publication details

Journal / source
European Journal of Medicinal Chemistry
Publisher
Elsevier BV
Volume
309
Pages
118743–118743
Publication date
6 March 2026
Language
EN