Design, synthesis, and integrated biological and molecular modeling studies of ciprofloxacin–amino acid derivatives as multi-target antimicrobials
Abstract
Fluoroquinolones are broad-spectrum antibacterials that exert their effects by inhibiting DNA gyrase and topoisomerase IV, enzymes crucial for bacterial DNA replication. Here, we report the synthesis of 60 novel ciprofloxacin-amino acid derivatives, designed to inhibit multiple bacterial targets by the so-called polypharmacology approach. Some of the synthesized compounds retained or improved the antibacterial potency against Gram-positive, Gram-negative, and mycobacterial species. Notably, some derivatives demonstrated promising activity (MIC
Fields of Study & Subjects
Cancer therapeutics and mechanisms
Antibiotics Pharmacokinetics and Efficacy
Synthesis and biological activity
Publication details
- Journal / source
- European Journal of Medicinal Chemistry
- Publisher
- Elsevier BV
- Volume
- 318
- Pages
- 119138–119138
- Publication date
- 9 July 2026
- Language
- EN