VIPs outperforms established models for predicting post-TIPS prognosis in viral hepatitis-dominant cirrhosis

BACKGROUND: Transjugular intrahepatic portosystemic shunt (TIPS) manages portal hypertension complications in cirrhosis, but predicting post-TIPS outcomes remains challenging, especially in viral hepatitis-dominated populations. PURPOSE: To systematically evaluate the predictive performance of the novel Viral-Associated Index of Post-TIPS Score (VIPs) for post-TIPS prognosis. We also comprehensively compare it with six established clinical prognostic models and one imaging-based model (the spleen volume-based model, SvBM). MATERIALS AND METHODS: ), and decision curve analysis (DCA) were also evaluated. RESULTS: = 0.121-0.142). Subgroup analyses further confirmed robust performance in females and patients with variceal bleeding. CONCLUSIONS: VIPs demonstrates superior predictive accuracy for post-TIPS survival in a viral hepatitis-dominated cohort and may serve as a preferred prognostic tool to guide individualized decision-making.