Low Urine Uromodulin Levels are Associated With Interstitial Fibrosis and Tubular Atrophy in Native Kidney Biopsies

Kidney International Reports 2026 Open access

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Authors: Manav Parikh, Heather Thiessen‐Philbrook, Dajun Hu, Jack Bitzel, Jiashu Xue, Serena DSouza, Rosenberg Avi Z., Dennis G. Moledina, Steven G. Coca, Chirag R. Parikh, Steven P. Menez
DOI: 10.1016/j.ekir.2026.106351
Cited by: 0
References: 8

Abstract

Interstitial fibrosis and tubular atrophy (IFTA) is a critical histological feature assessed in kidney biopsies, with its severity strongly correlating with long-term clinical outcomes, including progression to end-stage kidney disease.1-3 Although kidney biopsy remains the gold standard for diagnosis and evaluating specific histological features such as IFTA, noninvasive methods to assess IFTA would be highly valuable for disease management, especially among patients with absolute or relative contraindications to biopsy.

Fields of Study & Subjects

Chronic Kidney Disease and Diabetes Acute Kidney Injury Research Renal Diseases and Glomerulopathies

Publication details

Journal / source
Kidney International Reports
Volume
11
Issue
4
Pages
106351–106351
Publication date
12 February 2026
Language
EN