Serial Ultrastructural or Proteomic Observations in Light- and Heavy-Chain Deposition Disease

Kidney International Reports 2026 Open access

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Authors: Seiji Kakiuchi, Ikumi Takagi, Naru Tomigaki, Akimasa Sakamoto, Shutaro Fujioka, Isamu Harima, Hiroaki Akiyama, Ryotaro Niwa, Yoko Kozuki, Yoshiharu Miyata, Nobuko Iwata, Shigeo Hara
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DOI: 10.1016/j.ekir.2026.106380
Cited by: 1
References: 5

Abstract

Monoclonal gammopathy of renal significance (MGRS) encompasses kidney diseases caused by nephrotoxic monoclonal immunoglobulins produced by small B-cell or plasma cell clones.1 Light- and heavy-chain deposition disease (LHCDD) represents a rare subtype characterized by non-organized immunoglobulin deposits along renal basement membranes.2 Diagnosis can be challenging when routine immunofluorescence fails to detect immunoglobulin deposition, particularly in cases with atypical histologic features.

Fields of Study & Subjects

Enzyme Structure and Function Mass Spectrometry Techniques and Applications Advanced Electron Microscopy Techniques and Applications

Publication details

Journal / source
Kidney International Reports
Publisher
Elsevier BV
Volume
11
Issue
5
Pages
106380–106380
Publication date
24 February 2026
Language
EN