Randomized Controlled Study of Sirolimus-Coated Balloons for Dysfunctional Hemodialysis Fistulas

Kidney International Reports 2026 Open access

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Authors: Chieh Suai Tan, R K Tan, R K Tan, Pei Ho, Edward Tieng Chek Choke, Chee Wooi Tan, Chee Wooi Tan, Alvin Ren Kwang Tng, Gek Hsiang Lim, Hsien Ts’ung Tay, Kun Da Zhuang, Jun Jie Ng
+5 more Kalpana Vijaykumar, Darius Kang Lie Aw, Tze Tec Chong, Kiang Hiong Tay, Suh Chien Pang
DOI: 10.1016/j.ekir.2026.106583
Cited by: 1
References: 46

Abstract

Introduction Restenosis following balloon angioplasty remains a major cause of arteriovenous fistula (AVF) dysfunction in patients receiving maintenance hemodialysis. We evaluated whether use of sirolimus-coated angioplasty balloons (SCB) improves access circuit primary patency (ACPP) in patients with dysfunctional, non-thrombosed AVFs. Methods This investigator-initiated, multicenter, single-blinded, randomized controlled trial (ClinicalTrials.gov identifier: NCT04409912) enrolled 170 patients from three tertiary teaching hospitals in Singapore. Patients with dysfunctional AVFs, including those with single or multiple stenotic lesions within the access circuit, were included. Following successful plain balloon angioplasty (

Fields of Study & Subjects

Central Venous Catheters and Hemodialysis Dialysis and Renal Disease Management Infectious Aortic and Vascular Conditions

Publication details

Journal / source
Kidney International Reports
Publisher
Elsevier BV
Volume
11
Issue
8
Pages
106583–106583
Publication date
8 May 2026
Language
EN