Traffic-related air pollution in utero modifies cytokine responses to stimuli of umbilical cord blood cells: a cohort study

Environmental Research 2026 Open access

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Authors: Azahara M. García‐Serna, Elena Martín‐Orozco, Pedro Jiménez‐Guerrero, Trinidad Hernández‐Caselles, Esther Cantero‐Cano, María del Carmen Elena, Jesús Soler-Sánchez, Luis García‐Marcos, Eva Morales
DOI: 10.1016/j.envres.2026.123739
Cited by: 0
References: 43

Abstract

OBJECTIVE: To examine the associations between in utero exposure to traffic-related air pollutants (TRAP) and cytokine responses to stimuli in newborns. METHODS: ). Multivariable linear regression models were fitted. RESULTS: increase, 95 % CI: 0.1, 14.9) and decreased Th2-related IL-5 response to PAMPs PG (-6.7 %, 95 % CI: -12.8, -0.7) and pI:C (-7.6 %, 95 % CI: -14.2, -0.9). CONCLUSION: Prenatal exposure to TRAP may promote higher proinflammatory and Th1-related and lower Th2-related cytokine responses to stimuli in the offspring.

Fields of Study & Subjects

Air Quality and Health Impacts Birth Development and Health Heavy Metal Exposure and Toxicity

Publication details

Journal / source
Environmental Research
Volume
293
Pages
123739–123739
Publication date
8 January 2026
Language
EN