PP231 Development of a blood-based digital PCR assay using novel DNA methylation biomarkers for detecting early lung cancer

ESMO Open 2026 Open access

Read full text
Authors: Jin Soo Kim, Mi Young Kim, Yong Won Seong, Hyeon Jong Moon, Yun Young Lee, Jsoon An, Jinil Han, Youngho Moon
DOI: 10.1016/j.esmoop.2025.105993
Cited by: 0

Abstract

Early detection and treatment monitoring are crucial to improve clinical outcomes in lung cancer. Circulating tumor DNA (ctDNA) has rapidly emerged as a promising non-invasive tool, yet clinically validated biomarkers with high specificity and sensitivity remain limited. This study aimed to develop and validate a digital PCR-based liquid biopsy assay using novel DNA methylation biomarkers for lung cancer detection and disease monitoring.

Fields of Study & Subjects

Cancer Genomics and Diagnostics Epigenetics and DNA Methylation Lung Cancer Diagnosis and Treatment

Publication details

Journal / source
ESMO Open
Volume
11
Pages
105993–105993
Publication date
1 February 2026
Language
EN