291eP Whole-body MRI screening for Li-Fraumeni syndrome: The Irish experience

ESMO rare cancers. 2026 Open access

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Authors: Alice Talbot, N. Brady, Hugo C. Temperley, James F. Meaney, DJ Gallagher
DOI: 10.1016/j.esmorc.2026.100216
Cited by: 0

Abstract

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer syndrome associated with a high lifetime risk (∼70-100%) of cancer including breast cancer and sarcoma. International guidelines recommend annual whole-body MRI (WB-MRI) surveillance. Regional poor compliance with these guidelines has been reported due to resource constraints. We reviewed our country’s experience with LFS WB-MRI surveillance at a single centre where care is centralised and screening currently provided through philanthropically funded imaging when available.

Fields of Study & Subjects

MRI in cancer diagnosis BRCA gene mutations in cancer Multiple and Secondary Primary Cancers

Publication details

Journal / source
ESMO rare cancers.
Volume
5
Pages
100216–100216
Publication date
1 March 2026
Language
EN