34P Small-cell carcinoma of the ovary hypercalcaemic type (SCCOHT): A systematic review of molecular features, prognosis and therapeutic strategies

ESMO rare cancers. 2026 Open access

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Authors: Lamprini Basmpana, Stamatios Petousis, C. Margioula-Siarkou, Konstantinos D. Dinas
DOI: 10.1016/j.esmorc.2026.100241
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Abstract

Small-cell carcinoma of the ovary, hypercalcaemic type (SCCOHT) is an uncommon, highly aggressive neoplasm of young women, typically associated with paraneoplastic hypercalcaemia. The disease is molecularly defined by inactivation of the SWI/SNF ATPase SMARCA4 (BRG1), that has profound diagnostic and therapeutic implications. We undertook a systematic review to synthesise contemporary evidence on molecular hallmarks, prognostic determinants and therapeutic strategies.

Fields of Study & Subjects

Chromatin Remodeling and Cancer Ovarian cancer diagnosis and treatment BRCA gene mutations in cancer

Publication details

Journal / source
ESMO rare cancers.
Volume
5
Pages
100241–100241
Publication date
1 March 2026
Language
EN