171P High-density chemotherapy in patients with advanced sarcoma
Abstract
Chemotherapy (CT) is a standard treatment for advanced sarcomas; however, the outcomes have been disappointing over the last decades, even with high-dose or dose-dense regimens. We hypothesized that CT exposure is the trigger that activates, improves and enhances mechanisms of resistance. High-density chemotherapy (HDC) is a novel proposed treatment model developed at our institution. Based on short inter-cycle intervals and high exposure to CT, HDC could inhibit (avoid) resistance activation to cytotoxic drugs and reduce tumor repopulation.
Fields of Study & Subjects
Sarcoma Diagnosis and Treatment
Lymphoma Diagnosis and Treatment
Acute Myeloid Leukemia Research
Publication details
- Journal / source
- ESMO rare cancers.
- Volume
- 5
- Pages
- 100377–100377
- Publication date
- 1 March 2026
- Language
- EN