195P Reconstruction options for extensive femoral osteosarcoma: Nitrogen-frozen autograft–prosthesis composite or total femoral replacement?

ESMO rare cancers. 2026 Open access

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Authors: T.D. Nguyen, S.Q. Nguyen Tran Quang, Le Duc Huy, A. Luong, P.H. Luu, H. Le The, H.T. Le, H.T.T. Tran, Q.M. Dang, C. Tran Van, D. Nguyen, T. Duc Thanh
+1 more T.T. Dung
DOI: 10.1016/j.esmorc.2026.100401
Cited by: 0

Abstract

Limb-salvage for extensive femoral osteosarcoma is technically demanding and complication-prone. While total femoral replacement and long-segment biological reconstruction are standard, both carry substantial mechanical and biological failure rates. To address these limitations, we introduced a hybrid reconstruction using a liquid nitrogen–processed autologous femoral segment combined with a modular megaprosthesis (LN-MP) and compared it with conventional total femoral replacement (TFR).

Fields of Study & Subjects

Sarcoma Diagnosis and Treatment Bone Tumor Diagnosis and Treatments Orthopedic Infections and Treatments

Publication details

Journal / source
ESMO rare cancers.
Volume
5
Pages
100401–100401
Publication date
1 March 2026
Language
EN