A high-grade undifferentiated prostate malignancy in a young male suggestive of male adnexal tumour of Wolffian origin – A rare case and diagnostic challenge

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Authors: Rowan Klein Nulend, Kathleen Rebecca Lockhart, Kevin Tree, Linh N.K. TRAN, Bashar Matti, Yelise Foon, Ali Moghimi, Daniel WONG, Jordan BUTLER, Lawrence H.C. KIM, Audrey WANG, Manish I. Patel
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References: 13

Abstract

We report a rare case of a high-grade, poorly differentiated prostatic malignancy in a 24-year-old, initially presenting with haematuria and urinary retention following trauma. Imaging and cystoscopy revealed a large prostate mass. Although a final histopathological diagnosis could not be definitively determined, expert review suggests this may resemble a male adnexal tumour of Wolffian origin, an extremely rare pathology. The patient underwent neoadjuvant chemotherapy, followed by radical cystoprostatectomy and adjuvant radiotherapy. He remains in remission 18 months post-treatment. This case underscores the importance of thorough investigation and multidisciplinary management of rare, aggressive prostatic tumours in young patients.

Fields of Study & Subjects

Prostate Cancer Diagnosis and Treatment Urologic and reproductive health conditions Urinary and Genital Oncology Studies

Publication details

Journal / source
Urology Case Reports
Volume
65
Pages
103359–103359
Publication date
27 January 2026
Language
EN