Prospective Comparison of 64Copper [64Cu]SAR-bisPSMA vs 68Gallium[68Ga] PSMA-11 PET/CT for Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy (Co-PSMA Trial)

European Urology 2026 Open access

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Authors: Sobia Khan, Nathan Papa, Andrew Kneebone, Thomas Eade, Narjess Ayati, Andrew Nguyen, Keith Wong, Jeff Chen, Bao Ho, Jordan Idiare, George Sidhom, Matthew J Roberts
+12 more James Thompson, Shikha Sharma, Shraddha Weir, Katrina Devitt, Raji Kooner, Hester Lieng, Kris Rasiah, Joanna Olphert, Jeremy de Leon, George Hruby, Phillip D. Stricker, Louise Emmett
DOI: 10.1016/j.eururo.2026.03.001
Cited by: 4
References: 20

Abstract

BACKGROUND AND OBJECTIVE: Ga-PSMA) in BCR post radical prostatectomy (RP) (NCT06907641). METHODS: Cu-bisPSMA). The primary endpoint was mean per-participant lesional difference. Paired t tests and mixed-effects Poisson regression assessed lesion number differences between scans. KEY FINDINGS AND LIMITATIONS: Ga-PSMA, respectively. CONCLUSION AND CLINICAL IMPLICATIONS: Ga PSMA-PET/CT with substantial management impact and a high RS true positive rate in men with BCR post RP.

Fields of Study & Subjects

Prostate Cancer Treatment and Research Radiopharmaceutical Chemistry and Applications Prostate Cancer Diagnosis and Treatment

Publication details

Journal / source
European Urology
Publisher
Elsevier BV
Volume
89
Issue
6
Pages
512–520
Publication date
28 March 2026
Language
EN