Supplementation with conjugated linoleic acid ameliorates the level of some Nrf2-activated systemic markers in patients with amyotrophic lateral sclerosis: a proof-of-principle study

Free Radical Biology and Medicine 2026 Open access

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Authors: T. Biscardi, Roberta Pepe, E. Cortini, Diomira Luongo, Rosaria Notariale, Minoo Sharbafshaaer, Francesca Trojsi, Paolo Bergamo
DOI: 10.1016/j.freeradbiomed.2026.03.067
Cited by: 1
References: 57

Abstract

• Reliable redox/immune biomarkers were selected in the blood and RBCs of ALS patients • Six months of supplementation with CLA does not modify the ALS-FRS-R score • At T6, riluzole+CLA ameliorates the ALS-related decline in blood BDNF and P-SH levels • At T6, riluzole+CLA ameliorates ALS-related decrease of GSR and G6PD activity in RBCs • CLA supplementation moderates the decline of Nrf2-activated defences in ALS patients

Fields of Study & Subjects

Amyotrophic Lateral Sclerosis Research Genomics phytochemicals and oxidative stress Spondyloarthritis Studies and Treatments

Publication details

Journal / source
Free Radical Biology and Medicine
Publisher
Elsevier BV
Volume
250
Pages
312–320
Publication date
1 April 2026
Language
EN