The association of preoperative nutritional status and physical fitness with postoperative outcomes in esophageal cancer: results from the PReoperative intervention to Improve Outcomes in esophageal cancer patients after Resection study

PURPOSE: This study aimed to investigate whether preoperative nutritional status and physical fitness after prehabilitation are associated with surgical outcomes, functional capacity, fatigue, and quality of life after esophagectomy. METHODS: This multicenter, observational cohort study included patients with esophageal cancer who underwent curative treatment and multimodal prehabilitation as part of standard care. Preoperative assessments included body mass index (BMI), risk of malnutrition, exercise capacity, handgrip strength (HGS), upper leg muscle function, physical activity level, and fatigue, after finishing prehabilitation. Differences in preoperative parameters between patients with and without postoperative overall or pulmonary complications were analyzed using independent samples t-tests. Associations between preoperative parameters and length of hospital stay, postoperative functional capacity, fatigue, and quality of life were examined using multivariable linear regression models. RESULTS: A total of 168 patients were included in the study, with a mean age of 65.9 ± 8.6 years and 78.0% of the patients being male. A higher preoperative BMI was associated with more overall complications (P =.029). Better preoperative exercise capacity and upper leg muscle function were associated with less pulmonary complications (P