Small Extracellular Vesicles Released From Human Chemically Induced Liver Progenitors Have the Potential to Improve Liver Fibrosis in Mice

Gastro Hep Advances 2026 Open access

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Authors: Tomoko Yamaguchi, Juntaro Matsuzaki, Takeshi Katsuda, Kiminori Kimura, Hitoshi Tsugawa, Tohru Kiyono, Masaki Kimura, Marta Prieto‐Vila, Yuto Oshima, Yoshimasa Saito, Takahiro Ochiya
DOI: 10.1016/j.gastha.2026.100910
Cited by: 0
References: 10

Abstract

Liver fibrosis requires effective drug treatments because it is a leading cause of liver disease progression and cirrhosis.1 Cell therapy research, including mesenchymal stem cells (MSCs), is progressing; however, this approach carries the risk of immune rejection. We successfully generated rodent mature hepatocyte-derived liver progenitor cells, named chemically induced liver progenitors (CLiPs), by reprogramming rodent hepatocytes using small-molecule compounds.2 Rat CLiPs ameliorated fibrosis in an animal model that recapitulates metabolic dysfunction–associated steatohepatitis.

Fields of Study & Subjects

Extracellular vesicles in disease Liver physiology and pathology Mesenchymal stem cell research

Publication details

Journal / source
Gastro Hep Advances
Volume
5
Issue
5
Pages
100910–100910
Publication date
1 January 2026
Language
EN