Lecithin-Retinol Acyltransferase-Cre Exhibits Widespread Expression Beyond Hepatic Stellate Cells Across Multiple Tissues
Abstract
Hepatic stellate cells (HSCs) play a central role in liver fibrosis, shifting from quiescent vitamin A-storing cells to activated, myofibroblast-like cells that secrete collagen and other profibrotic factors.1 HSCs have thus become a major focus in liver fibrosis research, and several Cre driver lines have been created to target HSCs in mice. However, early Cre lines had significant limitations. Glial fibrillary acidic protein-Cre labels only a subset of HSCs and also induces recombination in cholangiocytes.
Fields of Study & Subjects
Liver physiology and pathology
Liver Disease Diagnosis and Treatment
Cholesterol and Lipid Metabolism
Publication details
- Journal / source
- Gastro Hep Advances
- Volume
- 5
- Issue
- 5
- Pages
- 100917–100917
- Publication date
- 1 January 2026
- Language
- EN