Points to consider for the reporting of variants of uncertain significance in germline genetic and genomic testing: A statement of the American College of Medical Genetics and Genomics (ACMG)

Chloe Mighton; Aya Abu‐El‐Haija; Vimla Aggarwal; Yassmine Akkari; Caroline Astbury; D. Hunter Best; Laura K. Conlin; Steven M. Harrison; Nan Jiang; Paul Kruszka; Dianalee McKnight; Tiffany T. Nguyen Dolphyn; Farid Barquet Ramos; Christie P. Thomas; Lora J.H. Bean; Heidi L. Rehm

doi:10.1016/j.gim.2026.102583

Points to consider for the reporting of variants of uncertain significance in germline genetic and genomic testing: A statement of the American College of Medical Genetics and Genomics (ACMG)

Genetics in Medicine 2026 Open access

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Authors: Chloe Mighton, Aya Abu‐El‐Haija, Vimla Aggarwal, Yassmine Akkari, Caroline Astbury, D. Hunter Best, Laura K. Conlin, Steven M. Harrison, Nan Jiang, Paul Kruszka, Dianalee McKnight, Tiffany T. Nguyen Dolphyn

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Farid Barquet Ramos, Christie P. Thomas, Lora J.H. Bean, Heidi L. Rehm

DOI: 10.1016/j.gim.2026.102583

Cited by: 6

References: 68

Fields of Study & Subjects

Genomics and Rare Diseases Genetic Associations and Epidemiology BRCA gene mutations in cancer

Publication details

Journal / source: Genetics in Medicine
Publisher: Elsevier BV
Volume: 28
Issue: 7
Pages: 102583–102583
Publication date: 12 June 2026
Language: EN

References 68