P005: Myelin lipid composition in adrenoleukodystrophy*

Genetics in Medicine Open 2026 Open access

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Authors: Nadav I. Weinstock, Ann Moser, Gerald V. Raymond, Christina L. Nemeth, Ali S. Fatemi
DOI: 10.1016/j.gimo.2026.103496
Cited by: 0

Abstract

Myelin is a highly specialized multilamellar membrane that ensheathes axons and enables rapid saltatory conduction. It is composed of specialized proteins and lipids, enriched for very long chain fatty acids (VLCFA, C≥22), including cholesterol esters, sphingolipids and phospholipids. Altered stoichiometry of these components can compromise membrane integrity and contribute to demyelination in leukodystrophy and neuropathy. Adrenoleukodystrophy (ALD) is the most common leukodystrophy, caused by pathogenic variants in ABCD1.

Fields of Study & Subjects

Metabolism and Genetic Disorders Lysosomal Storage Disorders Research Multiple Sclerosis Research Studies

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
103496–103496
Publication date
1 January 2026
Language
EN