P014: Unique perinatal growth phases of a Prader-Willi syndrome preclinical model

Genetics in Medicine Open 2026 Open access

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Authors: Oluwashanu Balogun, Robert D. Nicholls, Karli Bortner, James L. Resnick
DOI: 10.1016/j.gimo.2026.103505
Cited by: 0

Abstract

Prader-Willi syndrome (PWS) displays neonatal failure to thrive (FTT), hypotonia, hyperphagia, obesity, endocrine and metabolic deficits, with behavioral and cognitive impairments. Early dogma considered PWS as having two developmental stages: FTT in infancy followed by hyperphagia and obesity beginning in childhood. Conversely, natural history studies now delineate multiple nutritional phases including in utero, infancy with difficulty feeding and FTT, growth and weight gain without change in appetite, followed by increasing interest in food around ages 5-13 culminating in hyperphagia.

Fields of Study & Subjects

Genetic Syndromes and Imprinting Birth Development and Health Regulation of Appetite and Obesity

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
103505–103505
Publication date
1 January 2026
Language
EN