P058: Three-year use of risk-reducing interventions among cancer-free women with germline pathogenic variants in breast cancer predisposition genes*

Genetics in Medicine Open 2026 Open access

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Authors: Emily M. Russell, Sarah Nielsen Young, Rachel E. Ellsworth, Heidi Chwan Ko, Rebecca Previs, Erica M. Vaccari, Daniel E. Pineda-Alvarez, Edward D. Esplin, Kevin S. Hughes, Stacy W. Gray, Nadine Tung, Allison W. Kurian
DOI: 10.1016/j.gimo.2026.103549
Cited by: 0

Abstract

Risk-reducing (RR) surgeries and surveillance interventions in women with germline pathogenic variants (PV) in breast cancer predisposition genes include RR mastectomy (RRM), RR salpingo-oophorectomy (RRSO), enhanced breast imaging (breast MRI), and pancreatic cancer surveillance (endoscopic ultrasound [EUS] and/or MR cholangiopancreatography [MRCP]). We assessed use of RR interventions in women with PV in high/moderate risk breast cancer genes (ATM, BARD1, BRCA1/2, CDH1, CHEK2, NF1, PALB2, PTEN, RAD51C/D, STK11 and TP53).

Fields of Study & Subjects

BRCA gene mutations in cancer Breast Lesions and Carcinomas Women's cancer prevention and management

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
103549–103549
Publication date
1 January 2026
Language
EN