P081: Genomic alterations of Ph-like ALL: Summarizing genomic findings from over 100 cases of pediatric Ph-like acute lymphoblastic leukemia
Abstract
Philadelphia chromosome-like acute lymphoblastic leukemia/lymphoma (Ph-like ALL) is a high-risk B-lineage ALL subtype occurring in 10-15% of children and 25-30% of adolescents and young adults with B-ALL. Characterized by a kinase-activated gene expression profile, Ph-like ALL lacks the BCR::ABL1 fusion seen in Ph+ ALL. Instead, it features activating variants in JAK/STAT, ABL-class, or other kinase signaling pathways. This subtype is associated with high relapse rates and poor overall survival, underscoring the need for improved understanding of its genetic drivers.
Fields of Study & Subjects
Acute Lymphoblastic Leukemia research
Acute Myeloid Leukemia Research
Lymphoma Diagnosis and Treatment
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 103572–103572
- Publication date
- 1 January 2026
- Language
- EN