P087: Adherence to NCCN guidelines in patients with Lynch syndrome: A single institution study

Lynch Syndrome (LS), caused by germline pathogenic variants resulting in deficient DNA mismatch repair, is the most common inherited predisposition to colorectal cancer. Individuals with LS are also at elevated risk of endometrial, ovarian, gastrointestinal, and other cancers. The National Comprehensive Cancer Network (NCCN) provides recommendations for targeted surveillance and risk reduction in those with pathogenic variants in each related gene (MLH1, MSH2, MSH6, PMS2, EPCAM). At Montefiore Medical Center (Bronx, NY), guidelines are reviewed at the time of results disclosure and referrals placed to facilitate timely specialist consultation.