P095: Integrative tumor, germline and post-mortem analysis identifies a germline SMARCE1 driver in familial meningiomatosis

Genetics in Medicine Open 2026 Open access

Read full text
Authors: Kahlen R. Darr, Asma Ali, Gelareh Zadeh, Anne Elizabeth Bendel, Filippo Pinto e Vairo, Lisa A. Schimmenti
DOI: 10.1016/j.gimo.2026.103586
Cited by: 0

Abstract

The proband is status post complete tumor resection and undergoes surveillance through the Neuro-Oncology clinic at Mayo Clinic. Based on the recently published AACR guidelines, we recommended annual neurologic examination and MRI of the brain and spine from diagnosis until age 30, then every 2–3 years thereafter, or sooner if symptoms develop. Genetic counseling was provided to the family for discussion of surveillance, recurrence risk, and reproductive risk. Family variant testing was discussed with the family.

Fields of Study & Subjects

Meningioma and schwannoma management Neurofibromatosis and Schwannoma Cases Chromatin Remodeling and Cancer

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
103586–103586
Publication date
1 January 2026
Language
EN