P126: Detection rate and family-centered procedure of postmortem genetic testing for sudden unexplained death in the young: Systematic review and meta-analysis*

Postmortem genetic testing (PMGT) is a key approach for identifying genetic causes of sudden unexpected death in the young (SUDY). However, variations in study design, inclusion criteria, sample selection methods, and genetic analysis strategies make comparison of findings and assessment of the detection rate of PMGT difficult. Also, the implementation of PMGT varies across studies and regions, including pre-test explanation or consent and post-test genetic counseling or cascade testing. We conducted a systematic review and meta-analysis to estimate the detection rate of pathogenic variants identified by PMGT in SUDY cases aged 1–50 years, and to characterize contemporary PMGT practice, focusing on reporting of family-centered procedure before and after testing.