P164: Medical history of children with achondroplasia: Updated results from the global, prospective, observational PROPEL study

Genetics in Medicine Open 2026 Open access

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Authors: Julie Elizabeth Hoover-Fong, Josep Maria De Bergua, Ravi Savarirayan, Marie‐Eve Robinson, Saumya Shekhar Jamuar, Thomas Édouard, Svein O. Fredwall, Marc P Nicolino, Valérie Cormier‐Daire, Mars S. Skae, Mariana del Pino, Roberta Onesimo
+5 more Katja Palm, Elizabeth Freas, Karla Mehl, Lixin Zhang, Melita Irving
DOI: 10.1016/j.gimo.2026.103658
Cited by: 0

Abstract

Achondroplasia (ACH) is an FGFR3-driven skeletal dysplasia condition that can lead to various complications across an individual’s lifetime. A high number of medical conditions and events as well as interventions were previously described in children with ACH enrolled in the global, prospective, observational PROPEL study (n=97). Here, we report updated results from PROPEL with a larger cohort to further characterize the natural history of ACH.

Fields of Study & Subjects

Connective tissue disorders research Craniofacial Disorders and Treatments Growth Hormone and Insulin-like Growth Factors

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
103658–103658
Publication date
1 January 2026
Language
EN