P170: Systemic comorbidities in patients with a history of unexplained infertility: Preliminary findings from a single-institution
Abstract
Unexplained infertility is defined as the inability to conceive despite normal findings on a standard fertility evaluation. While traditionally regarded as an isolated reproductive condition, infertility is increasingly recognized as a potential marker of broader systemic health, and genetics could play a role. We recently found that women with unexplained infertility have a three-fold increased risk of pathogenic/likely pathogenic (P/LP) variants in medically actionable genes, most commonly predisposing to cancer and cardiovascular disease.
Fields of Study & Subjects
Reproductive Health and Technologies
Genomics and Rare Diseases
Prenatal Screening and Diagnostics
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 103664–103664
- Publication date
- 1 January 2026
- Language
- EN