P249: Age and colonoscopy history adjusted targets for precancerous polyps in individuals with Lynch syndrome

Genetics in Medicine Open 2026 Open access

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Authors: Kerri Conklin, Reilly Shapiro, Zhou Li, Sophia G. Blumenfeld, Rohan D. Patel, Douglas L. Riegert‐Johnson
DOI: 10.1016/j.gimo.2026.103743
Cited by: 0

Abstract

Individuals with Lynch syndrome have an increased risk of colorectal cancer. Current recommendations are for colonoscopy every one to three years to remove precancerous polyps (adenomas). The recommended interval between colonoscopies and colonoscopy starting age for Lynch syndrome individuals varies based on the mismatch repair (MMR) gene variant subtype. Individuals with high-risk genotypes (MLH1 and MSH2) initiate colonoscopies at a younger age and are recommended to have colonoscopies more frequently.

Fields of Study & Subjects

Genetic factors in colorectal cancer Colorectal Cancer Screening and Detection Colorectal Cancer Surgical Treatments

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
103743–103743
Publication date
1 January 2026
Language
EN