P506: Patient perspectives on communication and care after genetic variant reclassification
Abstract
Genetic variant classifications are not static – a variant initially reported with a specific classification may be reclassified over time as new evidence accumulates. Professional guidelines emphasize the importance of notifying patients when a prior test result is reclassified. However, little is known about how patients experience receiving a reclassified result. Existing studies suggest variable reactions, limited recall of updated classifications, and mixed emotional responses. However, more qualitative work is needed to understand how patients interpret and emotionally process reclassifications in different clinical contexts.
Fields of Study & Subjects
Genomics and Rare Diseases
Patient-Provider Communication in Healthcare
BRCA gene mutations in cancer
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 103998–103998
- Publication date
- 1 January 2026
- Language
- EN