P516: Risk-reducing mastectomy uptake among high-penetrance gene carriers: A real-world cohort study from Ramathibodi Hospital, Thailand
Abstract
Risk-reducing mastectomy (RRM) effectively lowers both breast cancer incidence and mortality among heterozygotes of high-penetrance pathogenic variants in genes such as BRCA1, BRCA2 and PALB2. Although hereditary breast cancer awareness has increased worldwide, information on RRM practices in Thailand remains limited. This study examined the rate of RRM among Thai women with pathogenic or likely pathogenic variants and explored factors influencing their surgical choices.
Fields of Study & Subjects
BRCA gene mutations in cancer
Breast Lesions and Carcinomas
Women's cancer prevention and management
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 104008–104008
- Publication date
- 1 January 2026
- Language
- EN