P529: Current practices in juvenile Huntington's disease epilepsy care
Abstract
Pediatric patients with Huntington’s disease (HD) present differently from adult-onset HD. Individuals with juvenile-onset HD (JHD), historically defined as onset before age 21 years, may present with oromotor dysfunction, parkinsonism, or declining school performance. Chorea is rare, and if present, is a late manifestation. Seizures may be a presenting symptom, and seizures ultimately occur in approximately 30-50% of individuals with JHD. In contrast, seizures are not a defining symptom of adult-onset HD and occur at the same rate as the general public (∼1%).
Fields of Study & Subjects
Genetic Neurodegenerative Diseases
Epilepsy research and treatment
Neurological and metabolic disorders
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 104021–104021
- Publication date
- 1 January 2026
- Language
- EN