P554: Unmasking biclonal FLT3-ITD: A hidden layer of clonal complexity in routine testing*

Genetics in Medicine Open 2026 Open access

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Authors: Xuemei Shi, Kritika Krishnamurthy, Abul Kalam Azad, Rizwan C. Naeem, D. Yitzchak Goldstein
DOI: 10.1016/j.gimo.2026.104045
Cited by: 0

Abstract

FLT3 internal tandem duplications (FLT3-ITD) occur in approximately 25% of newly diagnosed acute myeloid leukemia (AML) cases and portend poorer prognosis. Accurate detection of FLT3 variants is essential given their prognostic relevance and the incorporation of FLT3 inhibitors into standard chemotherapy protocols. However, the clinical impact of monoclonal vs multiclonal FLT3 remains insufficiently characterized.

Fields of Study & Subjects

Acute Myeloid Leukemia Research Retinoids in leukemia and cellular processes Protein Tyrosine Phosphatases

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
104045–104045
Publication date
1 January 2026
Language
EN