P619: AI-trained karyotyping algorithm facilitates the detection of abnormal clones that might otherwise remain undetected in B-cell ALL
Abstract
Hypodiploid B-cell lymphoblastic leukemia/lymphoma (B-ALL) is a rare and aggressive disease associated with poor prognosis. However, it can be difficult to identify cytogenetically. Hypodiploid cells often undergo endoreduplication, resulting in a doubled chromosome complement that appears in the patient’s karyotype. Importantly, this doubling occurs in vivo, as confirmed by DNA index studies of uncultured specimens, rather than being an artifact of cell culture.
Fields of Study & Subjects
Acute Lymphoblastic Leukemia research
Genomic variations and chromosomal abnormalities
Digital Imaging for Blood Diseases
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 104109–104109
- Publication date
- 1 January 2026
- Language
- EN