P636: Optimized DNA extraction from low-mass samples for HiFi long-read sequencing

Genetics in Medicine Open 2026 Open access

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Authors: Sarah B. Kingan, Shreyasee Chakraborty, Christine C. Lambert, Juiper Lake, Vicky Liu, Jeff Zhou, Davy Lee, Lin WANG, Heather Ferrao, Déborah Moine
DOI: 10.1016/j.gimo.2026.104126
Cited by: 0

Abstract

Large-scale genomic and clinical research studies frequently employ input-limited biological materials such as saliva and dried blood spots (DBS). Saliva represents a convenient and non-invasive sample type that can be collected using standardized devices, including Oragene (direct spit) and ORAcollect (sponge-based saliva collection). Similarly, DBS sampling offers a cost-effective approach that requires minimal blood volume and is routinely utilized in pediatric cohorts. Both sample types eliminate the need for cold-chain logistics, thereby reducing storage and transportation costs relative to whole blood.

Fields of Study & Subjects

Genomics and Phylogenetic Studies Genomics and Rare Diseases Genomic variations and chromosomal abnormalities

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
104126–104126
Publication date
1 January 2026
Language
EN