P650: Next generation sequencing for pediatric cancer predisposition: Analytical performance of a 137-gene panel

Genetics in Medicine Open 2026 Open access

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Authors: Bethany Van Asten, Christopher Frane, Alexander Peck, Carmen Noller, Yohyoh Wang, Chase Gomez, Lexie Lobo, Melinda Mundt, Brandie Heald, Karen White, Brett Deml, Tina M. Hambuch
+3 more Anthony D. Krentz, Melanie A. Jones, Piper Nicolosi
DOI: 10.1016/j.gimo.2026.104140
Cited by: 0

Abstract

Cancer predisposition syndromes (CPS), identified through germline genetic testing, account for approximately 7-15% of pediatric cancer diagnoses. This study aimed to develop and validate a next generation sequencing (NGS) panel for the detection of germline variants in genes associated with pediatric solid tumors and CPS.

Fields of Study & Subjects

BRCA gene mutations in cancer Genomics and Rare Diseases Cancer Genomics and Diagnostics

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
104140–104140
Publication date
1 January 2026
Language
EN