P681: Discrepant TP53 copy number results in molecular and cytogenetic testing for hematologic malignancies
Abstract
TP53 is an essential tumor suppressor gene altered in virtually all types of malignancies. Accurate assessment of TP53 alteration status is a critical component of a laboratory genetics workup for hematologic malignancies, as this biomarker can impact prognosis and treatment. TP53 is subject to sequence mutations, copy number alterations and chromosomal rearrangements, requiring a variety of cytogenetic and molecular assays for accurate detection. An emerging challenge in laboratory diagnostics is how to resolve discrepancies in TP53 copy number (CN) status across complementary techniques.
Fields of Study & Subjects
Genomic variations and chromosomal abnormalities
Cancer-related Molecular Pathways
Cancer Genomics and Diagnostics
Publication details
- Journal / source
- Genetics in Medicine Open
- Volume
- 4
- Pages
- 104171–104171
- Publication date
- 1 January 2026
- Language
- EN