O12: Comprehensive pan-cancer assessment of the APC I1307K variant reveals ancestry-independent colorectal cancer risk

Genetics in Medicine Open 2026 Open access

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Authors: Maksym Misyura, Chuan Gao, Zarina Yelskaya, Kanika Arora, Diana L. Mandelker
DOI: 10.1016/j.gimo.2026.104298
Cited by: 0

Abstract

The APC I1307K germline variant is a well-established risk factor for colorectal cancer (CRC) among individuals of Ashkenazi Jewish (ASJ) ancestry. However, its contribution to oncogenesis across other tumor types and ancestral backgrounds remains unclear.

Fields of Study & Subjects

Genetic factors in colorectal cancer BRCA gene mutations in cancer Genetic Associations and Epidemiology

Publication details

Journal / source
Genetics in Medicine Open
Volume
4
Pages
104298–104298
Publication date
1 January 2026
Language
EN